Cause of 500-year-old mystery epidemic identified


An excavated structure in Teposcolula-Yucundaa.

Christina Warinner; image courtesy of the Teposcolula-Yucundaa Archaeological Project

Researchers have cracked a nearly 500-year-old mystery about the germ that caused the so-called cocoliztli outbreak, an epidemic that killed countless indigenous people in Mesoamerica shortly after the Spaniards arrived in the New World.

The malady wasn’t smallpox, measles or another Old World disease; rather, it was likely Salmonella poisoning, the researchers concluded in a new study.

“We were successful in recovering information about a microbial infection that was circulating in this population,” study co-lead researcher Alexander Herbig, a scientist in the Department of Archaeogenetics at the Max Planck Institute for the Science of Human History (MPI-SHH), in Germany, said in a statement. [27 Devastating Infectious Diseases]

The 1545-1550 cocoliztli epidemic was immense, claiming victims in vast swaths of Mexico and Guatemala, including the Mixtec town of Teposcolula-Yucundaa, located in Oaxaca, Mexico. When the epidemic ended, the Mixtec moved their city from a mountaintop down into a valley next door, meaning their cemetery — filled with the bodies of those who succumbed to the epidemic — remained untouched for hundreds of years.

This cemetery was a scientific gold mine for researchers who were curious about the epidemic’s cause. To investigate, the team of scientists who wrote the new study carefully excavated the skeletal remains of 29 people buried in the Teposcolula-Yucundaa cemetery, and then used a computational program to identify ancient bacterial DNA within the samples.


A map (A) showing Teposcolula-Yucundaa in southern Mexico, including where the excavations took place and (B) a drawing of one of the individuals (C) that had Salmonella enterica.

Credit: Vågene, A.J. et al./Nature Ecology and Evolution

The program identified traces of the bacterium Salmonella enterica in 10 of the samples. Then, the researchers used a DNA enrichment technique to reconstruct S. enterica’s entire genome. This helped the researchers conclude that the 10 people were infected with a subspecies of Salmonella known as S. paratyphi C, which causes enteric fever, a category of fever that includes typhoid.

This discovery marks the first time that scientists have found microbial evidence of an S. enterica infection from ancient, New World samples, the researchers said.

Enteric fever can cause high fever, dehydration and gastrointestinal problems, and is still a major health threat today. There are about 21 million cases of thyphoid and 222,000 typhoid-related deaths worldwide every year, according to a 2014 estimate reported by the World Health Organization. However, little is known about its prevalence in ancient times, the researchers noted.

The study was published online Jan. 15 in the journal Nature Ecology and Evolution.

Original article on Live Science. All rights reserved.


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